Catalyst and solvent-free alkylation of quinoline N-oxides with olefins: A direct access to quinoline-substituted α-hydroxy carboxylic derivatives. Issue 9 (5th February 2016)

• Record Type: Journal Article
• Authors: Kumar, Rakesh; Kumar, Inder; Sharma, Ritika; Sharma, Upendra
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 9(2016)
• Page Start: 2613
• Page End: 2617
• Publication Date: 2016-02-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob02600h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A catalyst/solvent-free, one-pot and operationally simple method for the synthesis of quinoline-substituted α-hydroxy carboxylic derivatives by the hydroxyheteroarylation of olefins with quinoline N -oxides is reported. Abstract : A catalyst/solvent-free, one-pot and operationally simple method for the synthesis of quinoline-substituted α-hydroxy carboxylic derivatives by the hydroxyheteroarylation of olefins with quinoline N -oxides is reported. The reaction features a high atom-economy, mild and reagent/solvent-free conditions, broad substrate scope and good selectivity with high yields. A preliminary mechanistic study to shed light into the reaction pathway was also carried out.