Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD). Issue 5 (7th January 2016) - Palmer, Nick
Abstract : FBDD creates new opportunities for synthetic chemistry. Abstract : This study describes general synthesis aspects of fragments for FBDD, as illustrated by the dihydroisoquinolones1–3 . Previous Rh(iii ) methodology is extended to incorporate amines, heteroatoms (N and S), and substituents (halogen, ester) as potential binding groups and/or synthetic growth points for fragment-to-lead elaboration.