An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite. Issue 9 (21st January 2016)

• Record Type: Journal Article
• Authors: Zeidan, T. A.; Trotta, J. T.; Tilak, P. A.; Oliveira, M. A.; Chiarella, R. A.; Foxman, B. M.; Almarsson, Ö.; Hickey, M. B.
• Is Part Of: CrystEngComm. Volume 18:Issue 9(2016)
• Page Start: 1486
• Page End: 1488
• Publication Date: 2016-01-21
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c5ce02467f
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : Twelfth polymorph of the anti-psychotic drug aripiprazole was discovered where its active metabolite acted as a template during recrystallization. Abstract : A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.