Crystal engineered albendazole with improved dissolution and material attributes. Issue 9 (2nd February 2016)

• Record Type: Journal Article
• Authors: Thakur, Amitha; Thipparaboina, Rajesh; Kumar, Dinesh; Sai Gouthami, Kodukula; Shastri, Nalini R.
• Is Part Of: CrystEngComm. Volume 18:Issue 9(2016)
• Page Start: 1489
• Page End: 1494
• Publication Date: 2016-02-02
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c5ce02306h
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : Spherical agglomerates have shown 5.58 and 5.60 fold increases in AUC and DE, respectively when compared to ABZ at 6 hours. Abstract : Albendazole (ABZ) is a broad spectrum anthelminthic drug and is in the WHO list of essential medicines. It is a "brick dust" drug with very poor water solubility (0.2 pg ml −1 at 25 °C). In the present study, crystal engineering of ABZ was carried out using two different techniques: solvent recrystallization and spherical agglomeration. All the modified habits have shown improved dissolution and flow properties. Spherical agglomerates with HPC as a binder have shown a 5.60 fold enhancement in dissolution efficiency at the end of 6 h when compared to ABZ. The agglomerates with binder showed good compressibility and can be successfully used for direct tabletting.