Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors. Issue 15 (26th January 2016)
- Record Type:
- Journal Article
- Title:
- Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors. Issue 15 (26th January 2016)
- Main Title:
- Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors
- Authors:
- Diedrich, D.
Hamacher, A.
Gertzen, C. G. W.
Alves Avelar, L. A.
Reiss, G. J.
Kurz, T.
Gohlke, H.
Kassack, M. U.
Hansen, F. K. - Abstract:
- Abstract : A mini library of selective HDAC6 inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Abstract : A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as potent HDAC6 inhibitors with a selectivity over other HDAC isoforms. The most potent HDAC6 inhibitor revealed remarkable chemosensitizing properties and completely reverted the cisplatin resistance in Cal27 CisR cells.
- Is Part Of:
- Chemical communications. Volume 52:Issue 15(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 15(2016)
- Issue Display:
- Volume 52, Issue 15 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 15
- Issue Sort Value:
- 2016-0052-0015-0000
- Page Start:
- 3219
- Page End:
- 3222
- Publication Date:
- 2016-01-26
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5cc10301k ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2548.xml