An enantioselective three-component reaction of diazoacetates with indoles and enals by iridium/iminium co-catalysis. Issue 13 (13th January 2016)

• Record Type: Journal Article
• Authors: Li, Mingfeng; Guo, Xin; Jin, Weifeng; Zheng, Qing; Liu, Shunying; Hu, Wenhao
• Is Part Of: Chemical communications. Volume 52:Issue 13(2016)
• Page Start: 2736
• Page End: 2739
• Publication Date: 2016-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc09918h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The first example of chiral secondary amine and iridium(i ) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals was rationally designed and developed to afford 3-substituted indoles in good yields and with excellent enantioselectivity. Abstract : The first example of chiral secondary amine and iridium(i ) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals was rationally designed and developed to afford 3-substituted indole derivatives in good yields and with moderate diastereoselectivity as well as excellent enantioselectivity. This reaction is proposed to proceed through the enantioselective trapping of iridium(i )-associated zwitterionic intermediates via selective 1, 4-addtition to the chiral amine activated enals.