'Dual hit' metabolic modulator LDCA selectively kills cancer cells by efficient competitive inhibition of LDH-A. Issue 11 (6th January 2016)

• Record Type: Journal Article
• Authors: Ghosh, Monisankar; Saha, Suchandrima; Dutta, Samir Kumar
• Is Part Of: Chemical communications. Volume 52:Issue 11(2016)
• Page Start: 2401
• Page End: 2404
• Publication Date: 2016-01-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc09903j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Herein, we synthesize and elucidate the potential of a novel 'dual hit' molecule LDCA where it constitutively blocks lactate dehydrogenase isoform-A (LDH-A) to selectively subvert apoptosis and rigorously attenuate breast tumor progression in mice model. Abstract : Herein, we synthesize and elucidate the potential of a novel 'dual hit' molecule, LDCA, to constitutively block lactate dehydrogenase isoform-A (LDH-A) to selectively subvert apoptosis and rigorously attenuate breast tumor progression in a mouse model, comprehensively delineating the therapeutic prospectus of LDCA in the field of cancer metabolics.