A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells. Issue 13 (13th January 2016)

• Record Type: Journal Article
• Authors: Li, Dong-Peng; Wang, Zhao-Yang; Cao, Xiang-Jian; Cui, Jie; Wang, Xin; Cui, Hao-Zhong; Miao, Jun-Ying; Zhao, Bao-Xiang
• Is Part Of: Chemical communications. Volume 52:Issue 13(2016)
• Page Start: 2760
• Page End: 2763
• Publication Date: 2016-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc09092j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3 − /SO3 2− ) was presented. Abstract : A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3 − /SO3 2− ) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3 − /SO3 2− . Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.