A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions. Issue 11 (5th January 2016)

• Record Type: Journal Article
• Authors: Aryal, Gyan Hari; Battle, Cooper Hawkins; Grusenmeyer, Tod A.; Zhu, Mengyuan; Jayawickramarajah, Janarthanan
• Is Part Of: Chemical communications. Volume 52:Issue 11(2016)
• Page Start: 2307
• Page End: 2310
• Publication Date: 2016-01-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc08350h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A fluorescent sensor displaying a significant increase in emission upon binding CB[7] was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes. Abstract : A naphthalimide based fluorescent sensor displaying a significant increase in emission upon binding CB[7] with notable pH stability was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes. Previously unknown binders with moderate to strong affinities were discovered.