One-step ligand exchange and switching from hydrophobic to water-stable hydrophilic superparamagnetic iron oxide nanoparticles by mechanochemical milling. Issue 14 (21st January 2016)

• Record Type: Journal Article
• Authors: Korpany, Katalin V.; Mottillo, Cristina; Bachelder, Jill; Cross, Shoronia N.; Dong, Pengcheng; Trudel, Simon; Friščić, Tomislav; Blum, Amy Szuchmacher
• Is Part Of: Chemical communications. Volume 52:Issue 14(2016)
• Page Start: 3054
• Page End: 3057
• Publication Date: 2016-01-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc07107k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Mechanochemistry permits rapid solvent-free exchange of surface ligands on superparamagnetic iron oxide nanoparticles (IONPs), enabling control of surface properties. Abstract : We describe a simple, rapid methodology for the synthesis of water-stable iron oxide nanoparticles (IONPs) compatible with a variety of aqueous buffers, based on mechanochemical milling exchange of covalently bound surface ligands on pre-fabricated oleic acid-protected IONPs. Application of milling for IONP ligand exchange eliminates steps required for transforming hydrophobic into negatively charged, water-soluble superparamagnetic IONPs.