A novel voltammetric sensor employing zinc oxide nanoparticles and a new ferrocene-derivative modified carbon paste electrode for determination of captopril in drug samples. Issue 8 (9th February 2016)

• Record Type: Journal Article
• Authors: Karimi-Maleh, Hassan; Ahanjan, Kimia; Taghavi, Mehdi; Ghaemy, Mousa
• Is Part Of: Analytical methods. Volume 8:Issue 8(2016)
• Page Start: 1780
• Page End: 1788
• Publication Date: 2016-02-09
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c5ay03284a
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : A novel ferrocene-derivative (1, l′-bis(2-phenylethan-1-ol)ferrocene) as a catalyst for the voltammetric determination of captopril in pharmaceutical and biological compound analysis. Abstract : A novel 1, l′-bis(2-phenylethan-1-ol)ferrocene (1, 1′-BEOF) is synthesized and used for the modification of a carbon paste electrode in the presence of ZnO nanoparticles (ZnO/NPs) as a sensor in captopril (CAP) drug determination. The new sensor shows excellent electrocatalytic activity for the electro-oxidation of CAP and reduction of charge transfer resistance. The square wave voltammogram (SWV) currents increase linearly with CAP concentration in the oxidation range of 0.09–450.0 μmol L −1 and the detection limit for CAP was 0.05 μmol L −1 . The relative standard deviation for five successive assays of 10.0 μmol L −1 CAP was 1.9%. For further investigation, the novel sensor was employed for the determination of CAP in drug and urine samples.