Tertiary amino thiourea-catalyzed asymmetric cross aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones. Issue 11 (16th March 2016)

• Record Type: Journal Article
• Authors: Lutete, Léopold Mpaka; Miyamoto, Takashi; Ikemoto, Tetsuya
• Is Part Of: Tetrahedron letters. Volume 57:Issue 11(2016)
• Page Start: 1220
• Page End: 1223
• Publication Date: 2016-03-16
• Subjects: Aldol reaction -- Thiourea -- Bifunctional catalyst -- Organocatalysis -- Trifluoromethyl ketones; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.02.001
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An enantioselective aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones catalyzed by tertiary amino thiourea has been established. Under mild conditions, the corresponding β-trifluoromethyl-β-hydroxy ketone products were obtained with up to 89% ee.