Antidiabetic drugs. (March 2016)

• Record Type: Journal Article
• Authors: Waring, W Stephen
• Is Part Of: Medicine. Volume 44:Number 3(2016)
• Page Start: 138
• Page End: 140
• Publication Date: 2016-03
• Subjects: Acarbose -- antidiabetic -- DPP-IV inhibitor -- GLP-1 -- insulin -- meglitinides -- metformin -- overdose -- sulfonylureas -- thiazolidinediones; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Médecine factuelle -- Périodiques; Medicine; Periodicals; Electronic journals; Electronic journals; 610
• DOI: 10.1016/j.mpmed.2015.12.011
• Languages: English
• ISSNs: 1357-3039

Abstract

Abstract: Over recent years, there has been a rapid expansion of different classes of antihyperglycaemic drugs with diverse toxicological profiles. Insulin and sulfonylurea overdose can cause significant hypoglycaemia, which is reversed by administration of intravenous glucose 10–20%, aiming to achieve a target plasma glucose concentration of ≥4 mmol/litre. However, glucose alone is a potent stimulus for additional insulin release in sulfonylurea-poisoned patients and can result in recurrent and prolonged rebound hypoglycaemia. Octreotide inhibits the secretion of insulin from the pancreas and, when used in sulfonylurea poisoning, is associated with a marked reduction in hypoglycaemic episodes and glucose requirements.