Poly-arginine conjugated triarylmethyl radical as intracellular spin label. Issue 7 (1st April 2016)

• Record Type: Journal Article
• Authors: Driesschaert, Benoit; Bobko, Andrey A.; Eubank, Timothy D.; Samouilov, Alexandre; Khramtsov, Valery V.; Zweier, Jay L.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 7(2016)
• Page Start: 1742
• Page End: 1744
• Publication Date: 2016-04-01
• Subjects: EPR -- TAM -- Poly-arginine -- Radical -- Cyclic voltammetry; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.02.048
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Stable triarylmethyl radicals are ideal spin labels used for biomedical electron paramagnetic resonance applications. Previously reported structures exhibit polar charged functions for water solubilization preventing them from crossing the cell membrane. We report the synthesis of a triarylmethyl radical conjugated to poly-arginine peptide allowing intracellular delivery of the paramagnetic label.