The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders. Issue 7 (1st April 2015)

• Record Type: Journal Article
• Authors: Bi, Yingzhi; Dzierba, Carolyn D.; Fink, Cynthia; Garcia, Yudith; Green, Michael; Han, Jianxin; Kwon, Soojin; Kumi, Godwin; Liang, Zhi; Liu, Ying; Qiao, Ying; Zhang, Yulian; Zipp, Greg; Burford, Neil; Ferrante, Meredith; Bertekap, Robert; Lewis, Martin; Cacace, Angela; Westphal, Ryan S.; Kimball, David; Bronson, Joanne J.; Macor, John E.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 7(2015)
• Page Start: 1443
• Page End: 1447
• Publication Date: 2015-04-01
• Subjects: GPR88 -- GPC -- Agonists -- CNS -- Schizophrenia; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.02.038
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Modulating GPR88 activity is suggested to have therapeutic utility in the treatment of CNS disorders, such as schizophrenia. This Letter will describe the discovery and SAR development of a class of potent GPR88 agonists.