An efficient synthesis of [1, 3]dioxolo[4, 5-g]thieno[3, 4-b]quinolin-8(5H)-ones as novel thiazapodophyllotoxin analogues with potential anticancer activity. Issue 7 (1st April 2015)

• Record Type: Journal Article
• Authors: Li, Tuanjie; Lu, Ting; Yu, Chenxia; Yao, Changsheng
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 7(2015)
• Page Start: 1417
• Page End: 1419
• Publication Date: 2015-04-01
• Subjects: Thiazapodophyllotoxin -- Multicomponent synthesis -- Potential anticancer activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.02.047
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A catalyst-free synthesis of 6, 9-dihydro-[1, 3]dioxolo[4, 5- g ]thieno[3, 4- b ]quinolin-8(5 H )-ones as novel analogues of podophyllotoxins was developed by a three-component reaction of aldehydes, ethyl 2, 4-dioxotetrahydrothiophene-3-carboxylate and 3, 4-(methylenedioxy)aniline. This methodology not only provides new chemical library for the screening of anticancer activity, but also features excellent isolated yields, short reaction time, simple work up procedure and little environmental impact.