A coumarin lignanoid from the stems of Kadsura heteroclita. Issue 7 (1st April 2015)

• Record Type: Journal Article
• Authors: Su, Wei; Zhao, Jianping; Yang, Min; Yan, Hui-Wen; Pang, Tao; Chen, Sheng-Huang; Huang, Hui-Yong; Zhang, Shui-Han; Ma, Xiao-Chi; Guo, De-An; Khan, Ikhlas A.; Wang, Wei
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 7(2015)
• Page Start: 1506
• Page End: 1508
• Publication Date: 2015-04-01
• Subjects: Coumarin lignoid -- Coumarinlignan -- Kadsura heteroclita -- Anti-HBV activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.02.022
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Coumarinlignan (1 ), possessing a unique coumarin-containing lignan skeleton, was isolated from the stems of Kadsura heteroclita . Its structure and absolute configuration were determined by spectroscopic techniques, especially 2D NMR and X-ray crystallographic data analyses. The proposed biosynthetic pathway is discussed. This new compound showed good anti-HBV activity against HBeAg and HBsAg, and moderate anti-fibrotic and neuroprotective activities.