Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88. Issue 7 (1st April 2015) - Dzierba, Carolyn D.
Graphical abstract: Abstract: Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs have been prepared and evaluated for their GPR88 agonist activity and pharmacokinetic (PK) properties.