Our Odyssey with Functionalized Chiral Phosphines: From Optical Resolution to Asymmetric Synthesis to Catalysis. Issue 1 (18th November 2015)

• Record Type: Journal Article
• Authors: Chew, Renta Jonathan; Leung, Pak‐Hing
• Is Part Of: Chemical record. Volume 16:Issue 1(2016)
• Page Start: 141
• Page End: 158
• Publication Date: 2015-11-18
• Subjects: asymmetric synthesis -- hydrophosphination -- metallacycles -- P ligands -- palladium; Chemistry -- Periodicals; 540
• DOI: 10.1002/tcr.201500220
• Languages: English
• ISSNs: 1527-8999

Abstract

Abstract: Our journey in organophosphorus research over the past 26 years is compiled in this Personal Account. Advances in palladacycle design have engendered a shift in our focus from template‐mediated transformations to catalysis for the direct preparation of chiral phosphines containing a wide variety of functional groups. Novel approaches to access previously inaccessible phosphines and their applications in cancer research are summarized herein. Abstract : Our journey in organophosphorus research over the past 26 years is compiled in this Personal Account. Advances in palladacycle design have engendered a shift in our focus from template‐mediated transformations to catalysis for the direct preparation of chiral phosphines that contain a wide variety of functional groups. Novel approaches to access previously inaccessible phosphines and their applications in cancer research are summarized herein.