Findings in pancreatic MRI associated with pancreatic fibrosis and HbA1c values. Issue 3 (22nd July 2015)

• Record Type: Journal Article
• Authors: Noda, Yoshifumi; Goshima, Satoshi; Tanaka, Kaori; Osada, Shinji; Tomita, Hiroyuki; Hara, Akira; Horikawa, Yukio; Takeda, Jun; Kajita, Kimihiro; Watanabe, Haruo; Kawada, Hiroshi; Kawai, Nobuyuki; Kanematsu, Masayuki; Bae, Kyongtae T.
• Is Part Of: Journal of magnetic resonance imaging. Volume 43:Issue 3(2016)
• Page Start: 680
• Page End: 687
• Publication Date: 2015-07-22
• Subjects: pancreas -- magnetic resonance imaging -- pancreatic fibrosis -- HbA1c; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.25019
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Purpose: To evaluate the diagnostic performance of noncontrast‐enhanced magnetic resonance imaging (MRI) to grade pancreatic fibrosis and to assess hemoglobin (Hb) A1c values. Materials and Methods: Twenty‐nine consecutive patients with pancreatic or biliary malignancy who underwent pancreatectomy were evaluated. Patients were classified into three groups: HbA1c < 5.7 (group 1), 5.7 ≤ HbA1c < 6.5 (group 2), and HbA1c ≥ 6.5 (group 3). MRI of the pancreas was performed using a 1.5T MR system. The pancreas‐to‐muscle signal intensity ratio (SIR) on in‐ and opposed‐phase T 1 ‐, T 2 ‐, and diffusion‐weighted images, as well as the apparent diffusion coefficient were calculated. MRI measurements, degrees of pancreatic fibrosis, and HbA1c values were compared using multiple regression analysis and Kruskal–Wallis test. Results: The pancreatic fibrosis grade was negatively correlated with the SIR on in‐phase T 1 ‐weighted images ( r = –0.67, P = 0.0002). The pancreatic fibrosis grade and HbA1c value were negatively correlated with the SIR on opposed‐phase T 1 ‐weighted images ( r = –0.47, P = 0.019 and r = –0.51, P = 0.0089, respectively). SIRs on in‐ and opposed‐phase T 1 ‐weighted images were significantly lower in group 3 than in groups 1 and 2 ( P < 0.05). Conclusion: The pancreas‐to‐muscle SIRs on in‐ and opposed‐phase T 1 ‐weighted images could be a potential biomarker for pancreatic fibrosis and elevated HbA1c values. J. MAGN. RESON. IMAGING 2016;43:680–687.