Impact of arterial input function selection on the accuracy of dynamic contrast‐enhanced MRI quantitative analysis for the diagnosis of clinically significant prostate cancer. Issue 3 (25th August 2015)

• Record Type: Journal Article
• Authors: Azahaf, Mustapha; Haberley, Marc; Betrouni, Nacim; Ernst, Olivier; Behal, Hélène; Duhamel, Alain; Ouzzane, Adil; Puech, Philippe
• Is Part Of: Journal of magnetic resonance imaging. Volume 43:Issue 3(2016)
• Page Start: 737
• Page End: 749
• Publication Date: 2015-08-25
• Subjects: dynamic contrast‐enhanced MRI -- prostate cancer -- arterial input function -- pharmacokinetic analysis; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.25034
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Purpose: Using a limited temporal resolution dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) dataset to assess the impact of the arterial input function (AIF) choice on the transfer constant (K trans ) to distinguish prostate carcinoma (PCa) from benign tissue. Materials and Methods: Thirty‐eight patients with clinically important peripheral PCa (≥0.5 cc) were retrospectively studied. These patients underwent 1.5T multiparametric prostate MR with PCa and benign regions of interest (ROIs) selected using a visual registration with morphometric reconstruction obtained from radical prostatectomy. Using three pharmacokinetic (PK) analysis software programs, the mean K trans of ROIs was computed using three AIFs: an individual AIF (Ind‐AIF) and two literature population average AIFs of Weinmann (W‐AIF) and of Fritz‐Hansen (FH‐AIF). A pairwise comparison of the area under the receiver operating characteristic curves (AUROCC) obtained with different AIFs was performed. Results: AUROCCs obtained with W‐AIF (ranging from 0.801 to 0.843) were significantly higher than FH‐AIF (ranging from 0.698 to 0.780, 0.002 ≤ P ≤ 0.045) and similar to or higher than Ind‐AIF (ranging from 0.591 to 0.839, 0.014 ≤ P ≤ 0.9). Ind‐AIF and FH‐AIF provided similar AUROCC (0.34 ≤ P ≤ 0.81). The pairwise correlation of K trans values was moderate to very strong when comparing W‐AIF with FH‐AIF (the Spearman's correlation coefficients [SCCs] ranged from 0.55 to 0.93) and very weak to moderate when comparing W‐AIF with Ind‐AIF (the SCCs ranged from 0.018 to 0.59) or FH‐AIF with Ind‐AIF (the SCCs ranged from 0.30 to 0.51). Conclusion: W‐AIF yielded a higher performance than FH‐AIF and a similar or higher performance than Ind‐AIF in distinguishing PCa from benign tissue. J. MAGN. RESON. IMAGING 2016;43:737–749.