Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis. Issue 2 (28th September 2015)

• Record Type: Journal Article
• Authors: Reid, Michelle D.; Stallworth, Christina R.; Lewis, Melinda M.; Akkas, Gizem; Memis, Bahar; Basturk, Olca; Adsay, Volkan
• Is Part Of: Cancer cytopathology. Volume 124:Issue 2(2016)
• Page Start: 122
• Page End: 134
• Publication Date: 2015-09-28
• Subjects: cytology -- fine‐needle aspiration -- intraductal oncocytic papillary neoplasm (IOPN) -- intraductal papillary mucinous neoplasm (IPMN) -- oncocytic -- oncocytic intraductal papillary mucinous neoplasm -- pancreas; Cancer -- Cytopathology -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Technique -- Periodicals; 611.01815
• DOI: 10.1002/cncy.21627
• Languages: English
• ISSNs: 1934-662X

Abstract

Abstract : BACKGROUND: Cytologic findings of pancreatic oncocytic‐type intraductal papillary mucinous neoplasms (IPMNs)/intraductal oncocytic papillary neoplasms (IOPNs) are largely unknown. METHODS: Five IOPNs encountered by the authors were analyzed. RESULTS: Four IOPNs were located in the pancreatic head, and 1 was located in the pancreatic body/tail in 2 men and 3 women ages 56 to 84 years (mean age, 66 years). Radiologic diagnoses included pancreatic ductal adenocarcinoma (PDAC) in 2 patients, invasive cancer associated with IPMN in 1 patient, IPMN versus mucinous cystic neoplasm in 1 patient, and cystic mass in 1 patient. Cytologic findings included: hypercellular smears (4 of 5 cases) containing well formed clusters of oncocytic cells (5 of 5 cases) with prominent, slightly eccentric nucleoli (4 of 5 cases), predominantly arranged in sheets/papillary units (5 of 5 cases), with punched‐out intercytoplasmic spaces (4 of 5 cases), and with occasional 3‐dimensional groups and focal necrosis (3 of 5 cases). The intracytoplasmic mucin and thick extracellular mucin typical of other IPMNs were observed only in 2 cases and were very limited. The mean size on resection was 4.5 cm. Invasion was observed in 3 cases (0.1, 0.3, and 2.0 cm) of tubular‐type IPMN. Initial cytologic evaluation was performed by the authors in 4 of 5 cases, which were diagnosed as IOPN (n = 3) and IPMN versus cystic PDAC (n = 1). One case was initially misdiagnosed as PDAC and, on resection, proved to be noninvasive IOPN. CONCLUSIONS: Cytologic features of IOPNs are classical, similar to their histologic counterparts, and differ significantly from other IPMN subtypes. Because of their highly complex appearance, they are often radiologically misdiagnosed as PDAC; thus, failure to recognize their characteristic features on fine‐needle aspiration may lead to inappropriate treatment. Patients with IOPN have an incomparably better prognosis than patients with ordinary PDAC, even when their neoplasms are invasive. Cancer (Cancer Cytopathol) 2016;124:122–134. © 2015 American Cancer Society . Abstract : The cytologic features of oncocytic intraductal papillary mucinous neoplasms are classic and distinctive, and they are similar to those of their histologic counterparts. Failure to recognize these features on fine‐needle aspiration may lead to delayed resection and overtreatment with neoadjuvant chemoradiation, which is typically ineffective in these neoplasms which, even if invasive, have a better overall prognosis than invasive pancreatic ductal adenocarcinoma.