"Reactive nanoprecipitation": a one-step route to functionalized polylactide-based nanoparticles. Issue 125 (1st December 2015)

• Record Type: Journal Article
• Authors: Ficheux, Damien; Terrat, Céline; Verrier, Bernard; Gigmes, Didier; Trimaille, Thomas
• Is Part Of: RSC advances. Volume 5:Issue 125(2015)
• Page Start: 103060
• Page End: 103063
• Publication Date: 2015-12-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra21578a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : We report here a straightforward nanoprecipitation-based process to prepare functionalized polylactide (PLA) nanoparticles (NPs). Abstract : We report here a straightforward nanoprecipitation-based process to prepare functionalized polylactide (PLA) nanoparticles (NPs). It relies on an organic phase containing a PLA-based amphiphilic copolymer bearing N -succinimidyl esters that can spontaneously react with a peptide/protein located in the aqueous phase. The relevance of this strategy is supported by an improved antigenicity of immobilized HIV-1 Gag p24 protein.