Effects of biradical deuteration on the performance of DNP: towards better performing polarizing agents. Issue 1 (30th November 2015)

• Record Type: Journal Article
• Authors: Perras, Frédéric A.; Reinig, Regina R.; Slowing, Igor I.; Sadow, Aaron D.; Pruski, Marek
• Is Part Of: Physical chemistry chemical physics. Volume 18:Issue 1(2016)
• Page Start: 65
• Page End: 69
• Publication Date: 2015-11-30
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/c5cp06505d
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : We study the effects of the deuteration of biradical polarizing agents on the efficiency of dynamic nuclear polarization (DNP) via the cross-effect. Abstract : We study the effects of the deuteration of biradical polarizing agents on the efficiency of dynamic nuclear polarization (DNP) via the cross-effect. To this end, we synthesized a series of bTbK and TOTAPol biradicals with systematically increased deuterium substitution. The deuteration increases the radicals' relaxation time, thus contributing to a higher saturation factor and larger DNP enhancement, and reduces the pool of protons within the so-called spin diffusion barrier. Notably, we report that full or partial deuteration leads to improved DNP enhancement factors in standard samples, but also slows down the build-up of hyperpolarization. Improvements in DNP enhancements factors of up to 70% and time savings of up to 38% are obtained upon full deuteration. It is foreseen that this approach may be applied to other DNP polarizing agents thus enabling further sensitivity improvements.