One-pot preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams from acylhydrazines, trifluoroacetaldehyde methyl hemiacetal, allyl bromide and tin. Issue 4 (22nd December 2015)

• Record Type: Journal Article
• Authors: Du, Ganggang; Huang, Danfeng; Wang, Ke-Hu; Chen, Xiaowei; Xu, Yanli; Ma, Junyan; Su, Yingpeng; Fu, Ying; Hu, Yulai
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 4(2016)
• Page Start: 1492
• Page End: 1500
• Publication Date: 2015-12-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob02260f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Tin promoted one-pot preparation of trifluoromethylated homoallylic N -acylhydrazines or α-methylene-γ-lactams has been developed instead of using toxic stannanes. Abstract : An efficient and convenient one-pot method for the preparation of trifluoromethylated homoallylic N -acylhydrazines or α-methylene-γ-lactams has been described. In this process, allyl bromide and metal tin are used instead of toxic stannanes, and commercially available aqueous trifluoroacetaldehyde methyl hemiacetal was used as a trifluoromethyl source.