Elemental mapping of biological samples by the combined use of LIBS and LA-ICP-MS. Issue 1 (6th November 2015)

• Record Type: Journal Article
• Authors: Bonta, Maximilian; Gonzalez, Jhanis J.; Quarles, C. Derrick; Russo, Richard E.; Hegedus, Balazs; Limbeck, Andreas
• Is Part Of: Journal of analytical atomic spectrometry. Volume 31:Issue 1(2016:Jan.)
• Page Start: 252
• Page End: 258
• Publication Date: 2015-11-06
• Subjects: Atomic spectra -- Periodicals; Atomic absorption spectroscopy -- Periodicals; 543.0858
• DOI: 10.1039/c5ja00287g
• Languages: English
• ISSNs: 0267-9477

Abstract

Abstract : Feasibility of the simultaneous use of LIBS and LA-ICP-MS (tandem LA/LIBS) for bio-imaging of bulk and trace elements is demonstrated. Abstract : In this study a combination of Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and Laser Induced Breakdown Spectroscopy (LIBS) was used for laterally resolved elemental analysis of biological samples. In general LA-ICP-MS is an excellent technique for the analysis of many trace elements. However, bulk components such as H or O are not accessible using this technique. In addition to those elements, also some other elements that are difficult or impossible to investigate using LA-ICP-MS ( i.e., F, N, Cl, etc. ), could be detected by LIBS. In this work, the simultaneous use of LIBS and LA-ICP-MS (tandem LA/LIBS) for the analysis of biological samples is presented, opening the door for the possibility of complete analysis of the elemental composition of a human tumor sample. Results show good correlation with the histological stainings. The obtained distribution images provide a valuable basis for further medical interpretation.