Β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp3)–H bonds using a palladium catalyst. Issue 2 (26th November 2015)

• Record Type: Journal Article
• Authors: Peng, Jing; Chen, Chao; Xi, Chanjuan
• Is Part Of: Chemical science. Volume 7:Issue 2(2016:Feb.)
• Page Start: 1383
• Page End: 1387
• Publication Date: 2015-11-26
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5sc03903g
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Palladium catalyzed selective β -arylation of oxime ethers was realized using diaryliodonium salts as the key arylation reagents. Abstract : An efficient method of selective β -arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp 3 )–H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp 3 )–C(sp 2 ) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp 3 )–H functionalization.