The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. Issue 3 (27th November 2015)

• Record Type: Journal Article
• Authors: Bagley, Mark C.; Dwyer, Jessica E.; Baashen, Mohammed; Dix, Matthew C.; Murziani, Paola G. S.; Rokicki, Michal J.; Kipling, David; Davis, Terence
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 3(2016)
• Page Start: 947
• Page End: 956
• Publication Date: 2015-11-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob02229k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Microwave-assisted synthesis of the p38α MAPK inhibitor RO3201195 and its effect on the proliferation of Werner syndrome cells. Abstract : Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.