Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia. Issue 3 (30th November 2015)

• Record Type: Journal Article
• Authors: Zhang, Hua; Liu, Jia; Gan, Li-She; Dalal, Seema; Cassera, Maria B.; Yue, Jian-Min
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 3(2016)
• Page Start: 957
• Page End: 962
• Publication Date: 2015-11-30
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob02296g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Five new diterpenoid dimers of a rare structure class were discovered from Aphanamixis grandifolia . These compounds showed moderate antimalarial activities. Abstract : Chemical investigation into the minor constituents of Aphanamixis grandifolia yielded three new diterpenoid dimers, aphadilactones E–G (1–3 ) featuring a new carbon skeleton. Their structures and absolute configurations were fully established by comprehensive spectroscopic data analysis and ECD calculation. Discovery of another two new dimers (4 and5 ) suggested the structure of recently reported aphanamene A to be re-investigated. Compounds1–5 showed moderate antimalarial activities with low micromolar IC50 values.