Molecular modeling and synthesis of some new 2-imino-4-thiazolidinone derivatives with promising TNF-α inhibitory activity. (26th November 2015)

• Record Type: Journal Article
• Authors: Ali, Yakub; Alam, Mohammad Sarwar; Hamid, Hinna; Husain, Asif; Dhulap, Abhijeet; Hussain, Firasat; Bano, Sameena; Kharbanda, Chetna
• Is Part Of: New journal of chemistry. Volume 40:Number 1(2016:Jan.)
• Page Start: 711
• Page End: 723
• Publication Date: 2015-11-26
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c5nj00078e
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Out of 32 novel 2-imino-4-thiazolidinones, compounds3f &3g showed potent anti-inflammatory activity without causing any damage to the stomach. Abstract : A new series of thirty two 2-imino-4-thiazolidinone derivatives were synthesized, and the synthesized compounds were docked for in silico studies against the TNF-α target. The predicted results were confirmed through an in vitro TNF-α study which revealed that compounds3f and3g showed better TNF-α inhibition as compared to the standard drug indomethacin without causing any cytotoxicity. Fourteen compounds exhibiting significant in vitro TNF-α activity were further tested for in vivo anti-inflammatory activity by a carrageenan induced method. Compounds3f and3g showed better inhibition of inflammation in vivo as compared to the standard drug without causing any damage to the stomach. Furthermore, an immunohistochemical study showed that the compounds3f and3g exhibited better reduction in protein expression of TNF-α as compared to indomethacin. The in silico, in vitro and in vivo studies suggested that the compounds3f and3g might be considered as potent anti-inflammatory agents.