A catalyst free, multicomponent-tandem, facile synthesis of pyrido[2, 3-d]pyrimidines using glycerol as a recyclable promoting medium. (4th November 2015)

• Record Type: Journal Article
• Authors: Singh, Swastika; Saquib, Mohammad; Singh, Mandavi; Tiwari, Jyoti; Tufail, Fatima; Singh, Jaya; Singh, Jagdamba
• Is Part Of: New journal of chemistry. Volume 40:Number 1(2016:Jan.)
• Page Start: 63
• Page End: 67
• Publication Date: 2015-11-04
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c5nj01938a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient and green, one-pot synthesis of pyrido[2, 3- d ]pyrimidines, a biologically important heterocyclic scaffold, using glycerol as a promoter cum solvent. Abstract : A clean and efficient, multicomponent-tandem strategy for the synthesis of pyrido[2, 3- d ]pyrimidines is reported in glycerol, a biodegradable and reusable promoting medium. The advantages of the present methodology includes a one-pot catalyst free environmentally friendly approach, 100% atom economy, cost effectiveness, broad substrate scope, operational simplicity, short reaction times, easy workup procedure and high yields.