Efficacy of identifying neural components in the face and emotion processing system in schizophrenia using a dynamic functional localizer. (28th February 2016)

• Record Type: Journal Article
• Authors: Arnold, Aiden E.G.F.; Iaria, Giuseppe; Goghari, Vina M.
• Is Part Of: Psychiatry research. Volume 248(2016)
• Page Start: 55
• Page End: 63
• Publication Date: 2016-02-28
• Subjects: Schizophrenia -- Face perception -- Emotion processing -- Functional magnetic resonance imaging (fMRI) -- Functional localizer; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2016.01.007
• Languages: English
• ISSNs: 0925-4927

Abstract

Abstract: Schizophrenia is associated with deficits in face perception and emotion recognition. Despite consistent behavioural results, the neural mechanisms underlying these cognitive abilities have been difficult to isolate, in part due to differences in neuroimaging methods used between studies for identifying regions in the face processing system. Given this problem, we aimed to validate a recently developed fMRI-based dynamic functional localizer task for use in studies of psychiatric populations and specifically schizophrenia. Previously, this functional localizer successfully identified each of the core face processing regions (i.e. fusiform face area, occipital face area, superior temporal sulcus), and regions within an extended system (e.g. amygdala) in healthy individuals. In this study, we tested the functional localizer success rate in 27 schizophrenia patients and in 24 community controls. Overall, the core face processing regions were localized equally between both the schizophrenia and control group. Additionally, the amygdala, a candidate brain region from the extended system, was identified in nearly half the participants from both groups. These results indicate the effectiveness of a dynamic functional localizer at identifying regions of interest associated with face perception and emotion recognition in schizophrenia. The use of dynamic functional localizers may help standardize the investigation of the facial and emotion processing system in this and other clinical populations. Highlights: The localizer successfully engaged the core face processing system in patients and controls. The amygdala was localized in ~50% of both patients and controls. The localizer success rate did not significantly differ between groups. The localizer was effective at identifying the posterior superior temporal sulcus.