Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants. Issue 1 (30th September 2015)
- Record Type:
- Journal Article
- Title:
- Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants. Issue 1 (30th September 2015)
- Main Title:
- Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants
- Authors:
- Stephens, Matthew D.
Hubble, Veroncia B.
Ernst, Robert K.
van Hoek, Monique L.
Melander, Roberta J.
Cavanagh, John
Melander, Christian - Abstract:
- Abstract : A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia . Abstract : A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia . Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia .
- Is Part Of:
- MedChemComm. Volume 7:Issue 1(2016:Jan.)
- Journal:
- MedChemComm
- Issue:
- Volume 7:Issue 1(2016:Jan.)
- Issue Display:
- Volume 7, Issue 1 (2016)
- Year:
- 2016
- Volume:
- 7
- Issue:
- 1
- Issue Sort Value:
- 2016-0007-0001-0000
- Page Start:
- 128
- Page End:
- 131
- Publication Date:
- 2015-09-30
- Subjects:
- Pharmaceutical chemistry -- Periodicals
615.19 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/md ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5md00353a ↗
- Languages:
- English
- ISSNs:
- 2040-2503
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5424.685000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 79.xml