The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometria provides new insights into adenomyosis. Issue 2 (10th December 2015)

• Record Type: Journal Article
• Authors: Zhou, Cheng; Zhang, Ting; Liu, Fei; Zhou, Ji; Ni, Xiaobei; Huo, Ran; Shi, Zhonghua
• Is Part Of: Molecular bioSystems. Volume 12:Issue 2(2016:Feb.)
• Page Start: 362
• Page End: 370
• Publication Date: 2015-12-10
• Subjects: Molecular biology -- Periodicals; Biochemistry -- Periodicals; 571.7405
• DOI: 10.1039/c5mb00733j
• Languages: English
• ISSNs: 1742-206X

Abstract

Abstract : This work constitutes the first known report on lncRNA expression patterns of ectopic and eutopic endometrial tissues in human adenomyosis. Abstract : Adenomyosis, defined as ectopic endometrial tissue within the myometrium, can often be misdiagnosed as multiple uterine leiomyomata or endometrial thickening. We therefore performed a combined mRNA and long noncoding (lnc)RNA microarray and bioinformatic analysis of eutopic and ectopic endometria in women with adenomyosis to better understand its pathogenesis and help in the development of a semi-invasive diagnostic test. A total of 586 mRNAs were increased and 305 mRNAs decreased in the ectopic endometrium of adenomyosis compared with the eutopic endometrium, while 388 lncRNA transcripts were up-regulated and 188 down-regulated in ectopic compared with paired eutopic endometrial tissue. Bioinformatic analysis suggested a series of metabolic and molecular abnormalities in adenomyosis, which have many similarities with endometriosis. Furthermore, our study constitutes the first known report of lncRNA expression patterns in human adenomyosis ectopic and eutopic endometrial tissue.