Multifunctional Reduced Graphene Oxide (RGO)/Fe3O4/CdSe Nanocomposite for Electrochemiluminescence Immunosensor. (1st February 2016)

• Record Type: Journal Article
• Authors: Yang, Ying; Liu, Qiao; Liu, Xing-Pei; Liu, Ping-Zhen; Mao, Chang-Jie; Niu, He-Lin; Jin, Bao-Kang; Zhang, Sheng-Yi
• Is Part Of: Electrochimica acta. Volume 190(2016)
• Page Start: 948
• Page End: 955
• Publication Date: 2016-02-01
• Subjects: RGO/Fe3O4/PDDA/CdSe nanocomposite -- Magnetic -- Electrochemiluminescence -- immunosensor -- Interleukin-6; Electrochemistry -- Periodicals; Electrochemistry, Industrial -- Periodicals; 541.37
• DOI: 10.1016/j.electacta.2016.01.014
• Languages: English
• ISSNs: 0013-4686

Abstract

Abstract: A novel multifunctional reduced graphene oxide (RGO)/Fe3 O4 /PDDA/CdSe nanocomposite has been successfully prepared and used as probe for an electrochemiluminescence (ECL) immunosensor of human interleukin-6 (IL-6). The prepared RGO/Fe3 O4 /PDDA/CdSe nanocomposite was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), ultraviolet–visible (UV–vis) absorption spectroscopy, and a vibrating sample magnetometer (VSM). This nanocomposite shows magnetism, ECL properties, and good biocompatibility. Furthermore, the RGO/Fe3 O4 /PDDA/CdSe nanomaterial was applied to develop an ultrasensitive ECL immunosensor for detection of IL-6. The ECL intensity decreased linearly with the IL-6 concentrations in the range 0.002 to 20 ng/mL. Furthermore, the developed ECL immunosensor with high sensitivity, stability and excellent reproducibility can be used for detection of real samples, which make it possible to be used in clinical detection.