Dining in: intracellular bacterial pathogen interplay with autophagy. (February 2016)

• Record Type: Journal Article
• Authors: Winchell, Caylin G; Steele, Shaun; Kawula, Tom; Voth, Daniel E
• Is Part Of: Current opinion in microbiology. Volume 29(2016)
• Page Start: 9
• Page End: 14
• Publication Date: 2016-02
• Subjects: Microbiology -- Periodicals; 579.05
• DOI: 10.1016/j.mib.2015.09.004
• Languages: English
• ISSNs: 1369-5274

Abstract

Highlights: Intracellular bacterial pathogens must confront host cell autophagy to control infection. A subset of pathogens actively engages autophagy to promote infection and survival. Secreted bacterial proteins are responsible for many host cell exploitations. New mechanisms of bacterial interplay with autophagy have been discovered. Novel autophagy-related events provide insight into host cell responses and bacterial pathogenesis. Abstract : Intracellular bacterial pathogens have evolved many ways to manipulate host cells for successful infection. Many of these pathogens use specialized secretion systems to inject bacterial proteins into the host cytosol that manipulate cellular processes to favor infection. Autophagy is a eukaryotic cellular remodeling process with a critical role in many diseases, including bacterial clearance. A growing field of research highlights mechanisms used by intracellular bacteria to manipulate autophagy as a pro-survival strategy. This review focuses on a select group of bacterial pathogens with diverse intracellular lifestyles that exploit autophagy-derived nutrients and membrane for survival. This group of pathogens uses secretion systems and specific effectors to subvert distinct components of autophagy. By understanding how intracellular pathogens manipulate autophagy, we gain insight not only into bacterial pathogenesis but also host cell signaling and autophagolysosome maturation.