Cobaltoceniumethynyl gold(i) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes. Issue 4 (6th January 2016)

• Record Type: Journal Article
• Authors: Vanicek, S.; Kopacka, H.; Wurst, K.; Vergeiner, S.; Kankowski, S.; Schur, J.; Bildstein, B.; Ott, I.
• Is Part Of: Dalton transactions. Volume 45:Issue 4(2016)
• Page Start: 1345
• Page End: 1348
• Publication Date: 2016-01-06
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c5dt04796j
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A cobaltoceniumethynyl gold(i ) complex with a triphenylphosphane ligand triggered efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium moieties. Abstract : A cobaltoceniumethynyl gold(i ) complex with a triphenylphosphane ligand triggered efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium moieties. The complex effectively inhibited the enzyme thioredoxin reductase (TrxR) suggesting this enzyme as a possible biological target. The cellular uptake of both metal fragments of the active complex was studied by atomic absorption spectroscopy and indicated a high biological stability of the complex.