Cu2O rhombic dodecahedra as a superexcellent electroactive substance for ultrasensitive electrochemical immunosensors. Issue 6 (20th January 2016)

• Record Type: Journal Article
• Authors: Wang, Haining; Pan, Boguang; Feng, Taotao; Sun, Zhao; Dan, Jianming; Qiao, Xiuwen; Qi, Yu; Hong, Chenglin
• Is Part Of: Analytical methods. Volume 8:Issue 6(2016)
• Page Start: 1307
• Page End: 1312
• Publication Date: 2016-01-20
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c5ay03164h
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : Polydopamine functionalized Cu2 O rhombic dodecahedra as a superexcellent electroactive substance for ultrasensitive electrochemical immunosensors. Abstract : A novel biomolecular immobilization strategy based on a Cu2 O rhombic dodecahedra–polydopamine–gold nanoparticle nanocomposite was used for the detection of alpha-fetoprotein (AFP). Cu2 O rhombic dodecahedra, a new kind of Cu2 O nanocrystal with excellent catalytic properties, were coated with bio-functional polydopamine (PDA) using a simple self-polymerization in mild basic solution. Then, highly loaded and uniformly dispersed gold nanoparticles (Au NPs) were deposited on Cu2 O–PDA through in situ deposition. Under optimal conditions, a linear relationship between the CV peak current and the logarithm of the AFP concentration was obtained from 0.001 to 100 ng mL −1 with a detection limit of 0.6 pg mL −1 at a signal-to-noise ratio of 3. The high sensitivity and stability, low cost and simplicity in the fabrication procedures of the proposed immunosensor provide potential applications for clinical immunoassays.