Cobalt(iii) catalyzed C-8 selective C–H and C–O coupling of quinoline N-oxide with internal alkynes via C–H activation and oxygen atom transfer. Issue 7 (23rd December 2015)

• Record Type: Journal Article
• Authors: Barsu, Nagaraju; Sen, Malay; Premkumar, J. Richard; Sundararaju, Basker
• Is Part Of: Chemical communications. Volume 52:Issue 7(2016)
• Page Start: 1338
• Page End: 1341
• Publication Date: 2015-12-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc08736h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient, scalable, atom-economical, regio-selective air stable Cp*Co(iii ) catalyzed C–H and C–O coupling via a C–H activation/oxygen atom transfer reaction of quinoline N -oxide and an internal alkyne is reported. Abstract : An efficient, scalable, atom-economical, regio-selective air stable Cp*Co(iii ) catalyzed C–H and C–O coupling via a C–H activation/oxygen atom transfer reaction of quinoline N -oxide and an internal alkyne is reported. Such a catalytic transformation is witnessed for the first time with a cobalt catalyst and using N -oxide as a traceless directing group, in contrast to the existing literature. The developed synthetic methodology is straightforward and possesses various functional group tolerances, including heterocycles.