Incorporation of O6-methylguanine restricts the conformational conversion of the human telomere G-quadruplex under molecular crowding conditions. Issue 9 (17th December 2015)

• Record Type: Journal Article
• Authors: Zhao, Andong; Zhao, Chuanqi; Tateishi-Karimata, Hisae; Ren, Jinsong; Sugimoto, Naoki; Qu, Xiaogang
• Is Part Of: Chemical communications. Volume 52:Issue 9(2016)
• Page Start: 1903
• Page End: 1906
• Publication Date: 2015-12-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc09728b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : O 6 -methylguanine incorporation impeded the conformational conversion of G-quadruplex from a hybrid to a parallel structure under molecular crowding conditions. Abstract : Here we systematically studied the incorporation of O 6 -methylguanine (6mG) into different positions of the human telomere G-quadruplex. In contrast to the natural G-quadruplex, the 6mG incorporated G-quadruplexes impeded the conformational conversion of the G-quadruplex from a hybrid to a parallel structure under molecular crowding conditions in a K + containing buffer.