Copper mediated decarboxylative direct C–H arylation of heteroarenes with benzoic acids. Issue 7 (8th December 2015)

• Record Type: Journal Article
• Authors: Patra, Tuhin; Nandi, Sudip; Sahoo, Santosh K.; Maiti, Debabrata
• Is Part Of: Chemical communications. Volume 52:Issue 7(2016)
• Page Start: 1432
• Page End: 1435
• Publication Date: 2015-12-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc08367b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Copper mediated decarboxylative direct C–H arylation of 5-membered heteroarenes with aryl carboxylic acids is developed using the molecular oxygen as sole oxidant. Copper plays the dual role in decarboxylation and C–H arylation. Abstract : Decarboxylative coupling reactions to date require a stoichiometric oxidant (such as copper and silver salts) for decarboxylation purposes along with a metal catalyst ( e.g. palladium) for cross-coupling. In this communication, an economic and sustainable approach by using a simple copper salt was developed in the presence of molecular oxygen as the sole oxidant. A wide range of 5-membered heteroarenes undergo aryl–heteroaryl cross-coupling with electron deficient aryl carboxylic acids.