Angiotensin II analogs comprised of Pro-Amb (γ-turn scaffold) as angiotensin II type 2 (AT2) receptor agonists12. Issue 8 (14th December 2015)

• Record Type: Journal Article
• Authors: Jedhe, Ganesh S.; Kotmale, Amol S.; Rajamohanan, Pattuparambil R.; Pasha, Santosh; Sanjayan, Gangadhar J.
• Is Part Of: Chemical communications. Volume 52:Issue 8(2016)
• Page Start: 1645
• Page End: 1648
• Publication Date: 2015-12-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc09687a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Abstract : We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Solution-state NMR and CD studies suggest γ-turn-like conformation in Pro-Amb analogs in aqueous solution. Furthermore, Pro-Amb analogs have been shown to act as AT2 receptor agonists.