Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal. Issue 8 (15th December 2015)
- Record Type:
- Journal Article
- Title:
- Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal. Issue 8 (15th December 2015)
- Main Title:
- Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal
- Authors:
- Xu, Liang
Nussinov, Ruth
Ma, Buyong - Abstract:
- Abstract : Fluctuating N-terminal allosterically stabilize amyloid-β peptide hairpin by dissipating entropy into solvent. Abstract : Immobilized ions modulate nearby hydrophobic interactions and influence molecular recognition and self-assembly. We simulated disulfide bond-locked double mutants (L17C/L34C) and observed allosteric modulation of the peptide's intra-molecular interactions by the N-terminal tail. We revealed that the non-contacting charged N-terminal residues help the transfer of entropy to the surrounding solvation shell and stabilizing β-hairpin.
- Is Part Of:
- Chemical communications. Volume 52:Issue 8(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 8(2016)
- Issue Display:
- Volume 52, Issue 8 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 8
- Issue Sort Value:
- 2016-0052-0008-0000
- Page Start:
- 1733
- Page End:
- 1736
- Publication Date:
- 2015-12-15
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5cc08107f ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1435.xml