Synthesis of chiral α-hydroxy acids via palladium-catalyzed C(sp3)–H alkylation of lactic acid. Issue 9 (18th December 2015)
- Record Type:
- Journal Article
- Title:
- Synthesis of chiral α-hydroxy acids via palladium-catalyzed C(sp3)–H alkylation of lactic acid. Issue 9 (18th December 2015)
- Main Title:
- Synthesis of chiral α-hydroxy acids via palladium-catalyzed C(sp3)–H alkylation of lactic acid
- Authors:
- Chen, Kai
Li, Xin
Zhang, Shuo-Qing
Shi, Bing-Feng - Abstract:
- Abstract : A palladium-catalyzed alkylation of lactic acid with alkyl iodides is described. Abstract : Herein we report a Pd-catalyzed alkylation of lactic acid with the assistance of 8-aminoquinoline auxiliary. A wide range of alkyl iodides bearing β-hydrogen atoms are compatible with the reaction conditions, providing a practical and straightforward alternative to access chiral α-hydroxy acids (AHAs). The new reactions have been applied for the synthesis of isotope-labeled AHAs and a sugar-containing complex AHA.
- Is Part Of:
- Chemical communications. Volume 52:Issue 9(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 9(2016)
- Issue Display:
- Volume 52, Issue 9 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 9
- Issue Sort Value:
- 2016-0052-0009-0000
- Page Start:
- 1915
- Page End:
- 1918
- Publication Date:
- 2015-12-18
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5cc07879b ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 935.xml