A tri-serine tri-lactone scaffold for the quantification of citrate in urine. Issue 9 (15th December 2015)

• Record Type: Journal Article
• Authors: Akdeniz, Ali; Caglayan, Mehmet Gokhan; Anzenbacher, Pavel
• Is Part Of: Chemical communications. Volume 52:Issue 9(2016)
• Page Start: 1827
• Page End: 1830
• Publication Date: 2015-12-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc08759g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Tri-serine tri-lactone based fluorescent sensors can discriminate structurally similar anions, including mono-, di- and tri-carboxylates with 100% correct classification. Abstract : Tri-serine tri-lactone based C 3 symmetry fluorescent sensors were synthesized. Citrate is shown to bind to sensors, while displaying an increase in fluorescence intensity for the sensor with thiourea and a quenching for the sensor with sulfonamide. Information-rich responses of the sensors enable us to discriminate structurally similar anions, including mono-, di- and tri-carboxylates with 100% correct classification. A simple two-sensor array enables the determination of the concentration of citrate in urine without any sample preparation with high accuracy (error < 2%).