Synthesis of a far-red fluorophore and its use as an esterase probe in living cells. Issue 9 (15th December 2015)
- Record Type:
- Journal Article
- Title:
- Synthesis of a far-red fluorophore and its use as an esterase probe in living cells. Issue 9 (15th December 2015)
- Main Title:
- Synthesis of a far-red fluorophore and its use as an esterase probe in living cells
- Authors:
- Levine, Samantha R.
Beatty, Kimberly E. - Abstract:
- Abstract : A new esterase-activatable probe expands the toolkit for staining living cells with a far-red fluorescent carbazine. Abstract : We report the synthesis of a new far-red fluorophore, 1, 3-dichloro-7-hydroxy-2 H -spiro[acridine-9, 1′-cyclohexane]-2′, 5′-diene-2, 4′-dione (DSACO), which was modified to make two esterase probes: DSACO-2-AME and DSACO-7-AME. Both probes act as "turn-on" substrates for esterases and lipases. DSACO-2-AME exhibited efficient esterase-activated fluorescence inside living cells and is a stable, far-red alternative for the widely-used fluorescein diacetate.
- Is Part Of:
- Chemical communications. Volume 52:Issue 9(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 9(2016)
- Issue Display:
- Volume 52, Issue 9 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 9
- Issue Sort Value:
- 2016-0052-0009-0000
- Page Start:
- 1835
- Page End:
- 1838
- Publication Date:
- 2015-12-15
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5cc08764c ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 935.xml