A fast click–slow release strategy towards the HPLC-free synthesis of RNA. Issue 7 (1st December 2015)
- Record Type:
- Journal Article
- Title:
- A fast click–slow release strategy towards the HPLC-free synthesis of RNA. Issue 7 (1st December 2015)
- Main Title:
- A fast click–slow release strategy towards the HPLC-free synthesis of RNA
- Authors:
- Agustin, E.
Asare Okai, P. N.
Khan, I.
Miller, M. R.
Wang, R.
Sheng, J.
Royzen, M. - Abstract:
- Abstract : A general strategy for the purification of oligonucleotides synthesized by solid phase synthesis is described. Abstract : A general strategy for purification of oligonucleotides synthesized by solid phase synthesis is described. It is based on a recently developed concept involving a bio-orthogonal inverse electron demand Diels–Alder reaction between trans -cyclooctene and tetrazine, termed 'click-to-release'. The strategy has been applied towards the synthesis and purification of a model hairpin RNA strand, as well as a 34 nt long aptamer.
- Is Part Of:
- Chemical communications. Volume 52:Issue 7(2016)
- Journal:
- Chemical communications
- Issue:
- Volume 52:Issue 7(2016)
- Issue Display:
- Volume 52, Issue 7 (2016)
- Year:
- 2016
- Volume:
- 52
- Issue:
- 7
- Issue Sort Value:
- 2016-0052-0007-0000
- Page Start:
- 1405
- Page End:
- 1408
- Publication Date:
- 2015-12-01
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c5cc05392g ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 498.xml