Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. Issue 7 (10th December 2015)

• Record Type: Journal Article
• Authors: Ishii, Takehiko; Miyata, Kanjiro; Anraku, Yasutaka; Naito, Mitsuru; Yi, Yu; Jinbo, Takao; Takae, Seiji; Fukusato, Yu; Hori, Mao; Osada, Kensuke; Kataoka, Kazunori
• Is Part Of: Chemical communications. Volume 52:Issue 7(2016)
• Page Start: 1517
• Page End: 1519
• Publication Date: 2015-12-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc06661a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Monodispersed gold nanoparticles (AuNPs) were simultaneously decorated with lactosylated and non-modified shorter poly(ethylene glycol)s (PEGs) to enhance their target recognition. Abstract : Monodispersed gold nanoparticles (AuNPs) were simultaneously decorated with lactosylated and non-modified shorter poly(ethylene glycol)s (PEGs) to enhance their target recognition. The decoration with sufficiently shorter PEGs dramatically enhanced the multivalent binding ability of lactosylated AuNPs to the lectin-fixed surface, possibly due to the enhanced mobility of the ligands via the spacer effect generated by the shorter PEG chains.