Click and release: fluoride cleavable linker for mild bioorthogonal separation. Issue 5 (19th November 2015)

• Record Type: Journal Article
• Authors: Schneider, Elia M.; Zeltner, Martin; Zlateski, Vladimir; Grass, Robert N.; Stark, Wendelin J.
• Is Part Of: Chemical communications. Volume 52:Issue 5(2016)
• Page Start: 938
• Page End: 941
• Publication Date: 2015-11-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc07692g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A water dispersable, magnetic nanoparticle supported, bioorthogonal "click and release" system has been synthesized. Abstract : Herein, we present a water dispersable, magnetic nanoparticle supported "click and release" system. The cleavable linker has been synthesized by using a strain-promoted copper-free "click" reagent to establish the specific link and a fluoride cleavable silane moiety for mild cleavage. Small organic molecules, azide-bearing dyes and functionalized enzymes have been bound to the magnetic particle and released in a bioorthogonal way.