Carbamoyl anion-initiated cascade reaction for stereoselective synthesis of substituted α-hydroxy-β-amino amides. Issue 5 (18th November 2015)

• Record Type: Journal Article
• Authors: Lin, Chao-Yang; Ma, Peng-Ju; Sun, Zhao; Lu, Chong-Dao; Xu, Yan-Jun
• Is Part Of: Chemical communications. Volume 52:Issue 5(2016)
• Page Start: 912
• Page End: 915
• Publication Date: 2015-11-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc08118a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A carbamoyl anion-initiated cascade reaction with acylsilanes and imines allows rapid construction of substituted α-hydroxy-β-amino amides in high yields with excellent diastereoselectivities. Abstract : A carbamoyl anion-initiated cascade reaction with acylsilanes and imines has been used to rapidly construct substituted α-hydroxy-β-amino amides. The Brook rearrangement-mediated cascade allows the formation of two C–C bonds and one O–Si bond in a single pot. Using this approach, a range of α-aryl α-hydroxy-β-amino amides has been synthesized in high yields with excellent diastereoselectivities.